Blood biomarkers in a mouse model of CADASIL
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چکیده
منابع مشابه
Blood biomarkers in a mouse model of CADASIL
Mutations in NOTCH 3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a neurological disorder characterized by stroke, and vascular cognitive impairment and dementia. Loss of vascular smooth muscle cells (VSMC) and accumulation of granular osmiophilic material (GOM) deposits are hallmarks of CADASIL. There are no therapies fo...
متن کاملNovel pathological features and potential therapeutic approaches for CADASIL: insights obtained from a mouse model of CADASIL
1 Departments of Neurology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, Louisiana 71130, USA 2 Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, Louisiana 71130, USA 3 Department of Anatomy, Capital Medical University, Beijing 100069, China; Center of Parkinson's Disease, Beijing Institute for ...
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BACKGROUND AND PURPOSE CADASIL is an inherited small-vessel disease responsible for lacunar strokes and cognitive impairment. The disease is caused by highly stereotyped mutations in Notch3, the expression of which is highly restricted to vascular smooth muscle cells (VSMCs). The underlying vasculopathy is characterized by degeneration of VSMCs and the accumulation of granular osmiophilic mater...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2016
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2016.05.008